The Role of A2M in Cancer – a review (ISSN 2753-8176 (online))
The Role of A2M in Cancer – a review (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 CIC, U.K. info@gwyntwr1386.com Introduction Alpha-2-macroglobulin (α2M) is a large protein found in the blood which is mainly produced by the liver. α2M is the largest major non-immunoglobulin protein in human plasma (1). It functions as a broad-spectrum protease inhibitor which are involved in various biological processes such as inflammation, cell growth, and blood clotting (2). α2M can also bind to and regulate cytokines and growth factors, thus influencing the immune system response (3). α2M also may play a role in various cancers and has been implicated in the development of some cancers and also as a tumor suppressor in other cancer types (4). α2M may act as an anticancer agent by inhibiting proteases, which are enzymes that can promote tumor growth and metastasis. It can also bind to and neutralize growth factors and cytokines, potentially slowing down cancer cell proliferation (...