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 Putative breast cancer metastatic biomarkers in melanoma – short report (ISSN 2753-8176 (online))

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  Putative breast cancer metastatic biomarkers in melanoma – short report (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 CIC, U.K. info@gwyntwr1386.com We found out several putative plasma biomarkers for metastatic ER+ breast cancer prediction and diagnosis (1) and we decided to evaluate the presence of these biomarkers in lympathic fluid (LF) melanoma patient samples. We analyzed proteomic profiles of LF samples derived from control and melanoma patients detailed in table 1. We analyzed Mascot scores of specific proteins in each of these samples. We found out that Serum Amyloid A-1 protein (P0DJI8, SAA1)), inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3, Q06033-2), ceruloplasmin (P00450) and complement C4 β chain (B0UZ83) maybe relevant in melanoma progression. In table 2, are depicted our findings. SAA1 is not present in controls, but is significantly present in two of the no metastatic and two of the metastatic LF melanoma samples. Elevated circulat...
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Putative breast cancer metastatic biomarkers in melanoma - Coming soon!

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More articles coming in the end of October. Be aware!
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The Role of A2M in Cancer – a review (ISSN 2753-8176 (online))

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The Role of A2M in Cancer – a review (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 CIC, U.K. info@gwyntwr1386.com Introduction Alpha-2-macroglobulin (α2M) is a large protein found in the blood which is mainly produced by the liver. α2M is the largest major non-immunoglobulin protein in human plasma (1). It functions as a broad-spectrum protease inhibitor which are involved in various biological processes such as inflammation, cell growth, and blood clotting (2). α2M can also bind to and regulate cytokines and growth factors, thus influencing the immune system response (3). α2M also may play a role in various cancers and has been implicated in the development of some cancers and also as a tumor suppressor in other cancer types (4). α2M may act as an anticancer agent by inhibiting proteases, which are enzymes that can promote tumor growth and metastasis. It can also bind to and neutralize growth factors and cytokines, potentially slowing down cancer cell proliferation (...
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More articles coming in the end of August. Be aware!
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Can Hemoglobin be used to detect and monitor breast cancer progression? An A1C adapted POC test (ISSN 2753-8176 (online))

Can Hemoglobin be used to detect and monitor breast cancer progression? An A1C adapted POC test (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 592 Old Chester Road, Birkenhead, CH42 4NW, info@gwyntwr1386.com Background and Rationale Haemoglobin is a protein which is present in red blood cells and that is responsible for carrying oxygen from the lungs to body tissues and also for returning carbon dioxide from tissues to the lung. Low levels of hemoglobin (anemia) might be associated with cancer. A role for haemoglobin in cancer diagnosis in general is supported by a good number of publications. A previous work indicated the possibility of a direct relationship between the hemoglobin level and not only the early stages of cancer, but also the chemically induced precancerous condition (1). Interestingly, in patients with a diagnosis of primary lung, colorectal, breast or liver cancer, higher post-diagnosis haemoglobin change regardless of the b...
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A2M IN ACUTE LEUKEMIA - BRIEF REPORT (ISSN 2753-8176 (online))

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A2M IN ACUTE LEUKEMIA - BRIEF REPORT (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 592 Old Chester Road, Birkenhead, CH42 4NW, info@gwyntwr1386.com Introduction Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, where there is a rapid growth of abnormal cells that build up in the bone marrow and blood interfering with normal blood cell production (1). Here, we analyze by proteomic analysis the precipitates after ultra-centrifugation of the conditioned media resulting from the cell culture of OCI-AML3 and Kasumi1 cell lines. We compare these proteomic profiles with those derived from the precipitates after ultra-centrifugation of plasma samples of control adult males (Control plasma male 1 and Control plasma male 2) OCI-AML3 cell line is derived from a 57 year-old male with Adult acute myeloid leukemia (2). Kasumi1 cell line is derived from the peripheral blood of a male AML patient, 7 weeks old (3). Results and Discus...
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