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A2M IN GASTRIC CANCER (ISSN 2753-8176 (online))

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A2M IN GASTRIC CANCER (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Rd, Birkenhead, CH42 3XX. info@gwyntwr1386.com Gastric cancer is a cancer which develops from the lining of the stomach(1). The majority of the cases are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinoma (2). Unfortunately, early gastric cancer causes few symptoms and the disease is usually advanced when the diagnosis is made being difficult to treat (3). We analyzed by proteomics the secretion of A2M by different gastric cancer cell lines derived from primary tumor tissues (4) or lymph node metastases (5) or stage IV tumors (6) in cell culture. We found out that (table 1), A2M presents significant scores in primary gastric cancer cell lines and in lymph node metastases cell lines, whereas is not present or is present in a non-significant way in gastric cancer stage IV cell lines. This points out a role for A2M in gastric...
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Can Hemoglobin be used to detect and monitor cancer progression? An update (ISSN 2753-8176 (online))

Can Hemoglobin be used to detect and monitor cancer progression? An update (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com The rationale for developing a lab based assay for cancer - Mammography screening is meant to reduce breast cancer mortality through early diagnosis and treatment of disease that would otherwise threaten life. However, in some cases a screening mammogram detects a cancer that would have neither caused death nor presented clinically during the woman’s lifetime. It is clear that to reduce the burden of over diagnosis on both the emotional and physical health of the patient and the economic health of the NHS, more sensitive tests for the diagnosis of breast cancer are needed (1, 1b, 1c). An hemoglobin based test would be very specific, unexpensive and very accessible as for the reasons detailed below. - Total hemoglobin and different hemoglobin subunits seem to be assoc...
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A social Cafe to tackle drug addiction (ISSN 2753-8176 (online))

A social Cafe to tackle drug addiction (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com Description of the innovation To set up Netherlands bulldog like cafes at the NHS where you can freely consume cannabis, cocaine, methamphetamide, etc for free and moreover you can have a free delicious meal and enrolling different healthy activities. What problem is your innovation trying to solve? Drug addiction What diseases or conditions does your innovation impact? Mental health and behavioural conditions - Drug misuse
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A2M in Prostate Cancer – short report (ISSN 2753-8176 (online))

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A2M in Prostate Cancer – short report (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. We study the possibility that A2M can play a role in prostate cancer (PC) progression. Prostate cancer is the second most common type of cancer in the world. Moreover, is the fifth leading cause of cancer-related mortality among men (1). About 99% of cases occur after age 50 (1). Early prostate cancer symptoms are often similar to those of benign prostatic hyperplasia and include frequent urination, nocturia (increased urination at night), difficulty starting and maintaining a steady stream of urine, hematuria (blood in the urine), dysuria (painful urination) as well as fatigue due to anemia, and bone pain (1). Like early cancer, meta...
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A2M in Lung Cancer – short report (ISSN 2753-8176 (online))

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A2M in Lung Cancer – short report (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. We study the possibility that A2M can play a role in lung cancer initiation and/or progression. Here we analyse by proteomic analysis, the presence of A2M (P010230) in the precipitates derived from conditioned media of different lung cancer cell lines and lung cancer-derived bone metastases (mets) (table 1). We find out that control cell WI38 presents quite a big Mascot score (993), while primary lung cancer cell lines present an average Mascot score level (315-415)...
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A2M in Colorectal Cancer (ISSN 2753-8176 (online))

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A2M in Colorectal Cancer (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Colorectal cancer (CRC), is the development of cancer from the colon or rectum (parts of the large intestine). Staging of the cancer is based on both radiological and pathological findings. As with most other forms of cancer, tumor staging is based on the TNM system which considers how much the initial tumor has spread and the presence of metastases in lymph nodes and more distant organs. We analyze the possibility that A2M (alpha-2-macroglobulin) can play a role in CRC initiation and/or progression. Here, we analyze by proteomics the presence of A2M in the conditioned culture media of different CRC cell lines either overexpressing P53 or knockout for P53 (3) or treated with vitamin D and from different stages of tumor progression and benign tissues (table 1). We found out th...
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A2M function in pancreatic cancer in mouse (ISSN 2753-8176 (online))

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A2M function in pancreatic cancer in mouse (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Introduction, results and discussion In our previous article we analyzed the hypothesis that A2M predicts cancer appearance or progression in the breast (1) and in the skin (2), now we analyse if this hypothesis might be true as well in the case of pancreatic cancer in mouse. The most common type of pancreatic cancer (PC) is adenocarcinoma, which accounts for 90% of the cases. Around 1-2% of the PC cases have a neuroendocrine origin, arising from the hormone-producing cells of the pancreas being in general less aggressive than the adenocarcinoma (3). In table 1, we found Mascot scores for two different mouse normal pancreas tissue CM samples (one shows a significant Mascot Score, while the other shows no A2M), PanIn cell ...
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