THE ROLE OF HEMOGLOBIN IN CANCER – AN OPINION (ISSN 2753-8176 (online), DOI:10.13140/RG.2.2.17696.97281)
THE ROLE OF HEMOGLOBIN IN CANCER – AN OPINION ISSN 2753-8176 (online), DOI:10.13140/RG.2.2.17696.97281 Ana Pedro1 1Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK We have identified by proteomics analysis a possible biomarker for early stage ER+ breast cancer (BC), HCG1745306 isoform CRA-a, an isoform of haemoglobin subunit alpha (HBA) (1). A large body of evidence supports a role for haemoglobin not only in BC diagnosis but also in cancer diagnosis in general. HBA has also been previously found to be upregulated in the urine of patients with early invasive BC (2). Also, previous work indicated the possibility of a direct relationship between the hemoglobin level and not only the early stages of cancer, but also the chemically induced precancerous condition (3). Total haemoglobin (THC) has been shown to be present in higher concentrations in breast tumours in comparison to healthy tissues while oxyhemoglobin has been showed to be reduce