A2M in Colorectal Cancer (ISSN 2753-8176 (online))
A2M in Colorectal Cancer (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Colorectal cancer (CRC), is the development of cancer from the colon or rectum (parts of the large intestine). Staging of the cancer is based on both radiological and pathological findings. As with most other forms of cancer, tumor staging is based on the TNM system which considers how much the initial tumor has spread and the presence of metastases in lymph nodes and more distant organs. We analyze the possibility that A2M (alpha-2-macroglobulin) can play a role in CRC initiation and/or progression. Here, we analyze by proteomics the presence of A2M in the conditioned culture media of different CRC cell lines either overexpressing P53 or knockout for P53 (3) or treated with vitamin D and from different stages of tumor progression and benign tissues (table 1). We found out th...