Gwyntwr1386 Science Journal

An E-Medicine Delivery and Treatment Monitoring Service For Patients With Type-2 Diabetes In The NHS - Project proposal Ana Pedro 1 1 Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK There is a high prevalence of diabetes and it continues to increase. The adherence to oral antidiabetics ranges from 36% to 93% (1). Moreover, improving the adherence to treatment in diabetes patients will lead to a better glycaemic control and could in the longterm reduce the incidence of micro- and macrovascular complications associated with diabetes (2,3). Also, most MCA (medicine-compliance aids) patients are elderly and suffer of combined cardiovascular disease including diabetes (4). Gwyntwr1386 Pharmacy, intends to provide a new, online clinical delivery and treatment monitoring service for the NHS based on a blister-pack and its external medication, a monitoring POC device and a web platform. In an automated fashion, this will deliver medication in ...

The effects of MTC analogues in the cell cycle, cytoskeleton and apoptosis pathways in HeLa cells Ana Pedro 1 1 Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK MTC (2-Methoxy-5-(2’, 3’, 4’-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-one) is a bicyclic colchine analogue synthesized by Fitzgerald (1) and induces microtubule disruption quickly and reversibly (2, 3) leading to a G2/M cell cycle arrest what culminates in apoptosis in human leukemic cells (Gajate et al, 2000, 4). In order to unveil what MTC molecule parts or functional groups are important in G2/M arrest and apoptosis triggering, MTC analogues TKB, TCB, TMB were tested in different concentrations (Fig.1). MTC does nor have the B ring of colchicine (green arrow) and MTC analogues miss the carbonyl group of MTC (blue arrow). Cell cycle analysis We found that at 10-6, TCB and TMB did not exert any significant effect in HeLa cells, at 10-5 M, TMB arrested cells in G2/M ...