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Viruses, extracellular vesicles (EVs) and extracellular particles (EPs): a crisis of scientific concepts? DOI:10.13140/RG.2.2.18072.06408, ISSN 2753-8176 (online) - Opinion

Ana Pedro1 1Gwyntwr1386 Healthcare CIC, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK Viruses are defined as submicroscopic infectious agents which can only replicate inside the living cells of an organism. Supposedly, viruses are able to infect animals and plants to microorganisms, including bacteria and archea. Moreover, when not inside the cells they infected, viruses exist in the form of individual particles, named virions. Virions are composed accordingly to literature by genetic material (DNA or RNA which encode the structure of the proteins by which the virus acts); by a protein coat, the capsid, which surrounds and protects the genetic material; and in some cases an outside envelope of lipids (1). Curiously, extracellular vesicles (EVs) are lipid bilayer-delimited particles which are naturally released from almost all types of cells and cannot replicate alone as well. Similarly to virions they carry also carry proteins, nucleic acids and lipids(2). Moreover, e...