A possible function for P21 CDKN1A in a mid-pachytene/XY body checkpoint in mouse spermatocytes – short report ISSN 2753-8176 (online), DOI:10.13140/RG.2.2.10079.94880
A possible function for P21 CDKN1A in a mid-pachytene/XY body checkpoint in mouse spermatocytes – short report ISSN 2753-8176 (online), DOI:10.13140/RG.2.2.10079.94880 Ana Pedro1 1Gwyntwr1386 Healthcare CIC, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK Keywords: P21 CDKN1A, mid-pachytene checkpoint, XY body 1. Corresponding author: anapedrolaboratories@gmail.com. It was suggested the existence of a mid-pachytene checkpoint where this checkpoint could be activated at the earliest at stage IV (1). On a previous publication (2), we found that the cyclin dependent kinase inhibitor P21 CDKN1A might be involved in a mid-pachytene checkpoint among other checkpoints in the mouse seminiferous epithelium. Mice deficient for Atm are male sterile with arrest and apoptosis occurring at testis epithelial stage IV, which in normal spermatocytes corresponds to mid-pachynema (3). In Atm/p53 or Atm/p21 double mutants, assembly of Rad51 foci on axial elements is defective, and ga...