Possible functions of P21 CDKN1A within mouse spermatogonia ISSN 2753-8176 (online) (DOI: 10.13140/RG.2.2.27322.06086)
Possible functions of P21 CDKN1A within mouse spermatogonia Ana Pedro 1 1 Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK DOI: 10.13140/RG.2.2.27322.06086 Abstract The cyclin dependent kinase inhibitor P21 CDKN1A is upregulated during differentiation and upon DNA damage in somatic cells. We analysed the expression of P21 CDKN1A , γ-H2AX, PCNA and BrDu in differentiating mouse spermatogonia in mouse testis. P21 CDKN1A was expressed in in a variable manner in different spermatogonia types such as spermatogonia A and B. In addition, in agreement with γ-H2AX, PCNA and BrDu expression, P21 might have roles in cell cycle checkpoints, chromosome instability, replication, mitosis control and DNA repair but not apoptosis in spermatogonia. Keywords: P21 CDKN1A, Spermatogonia 1. Corresponding author: anapedrolaboratories@gmail.com The cyclin dependent kinase inhibitor P21 CDKN1A is upregulated during differentiation and upon DNA ...