Posts

Does A2M predicts cancer appearance or progression in skin? (ISSN 2753-8176 (online))

Image
Does A2M predicts cancer appearance or progression in skin? (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Introduction In our previous article we analyzed the hypothesis that A2M predicts cancer appearance or progression in the breast (1), now we analyse if this hypothesis might be true as well in the case of the skin. The interstitial fluid and the deriving lymph are in direct contact with the cellular layer of each organ. Therefore, the analysis of the composition of the lymphatic fluid (LF) may provide precise pathological biochemical and cellular information about an organ including the skin (2). For these reasons, we collected LF samples both from healthy patients and cutaneous melanoma (CM) patients suffering from different stages of the disease, and submitted these samples to proteomic analysis and analyzed the expression of A2M in these sa...
Post a Comment
Read more

Does Alpha-2-macroglobulin (α2M) predicts breast cancer development or progression? (ISSN 2753-8176 (online))

Image
Does Alpha-2-macroglobulin (α2M) predicts breast cancer development or progression? (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD, info@gwyntwr1386.com Introduction, Results and Discussion Alpha-2-macroglobulin (α2M) is a large protein found in the blood which is mainly produced by the liver. α2M is the largest major non-immunoglobulin protein in human plasma (1). It functions as a broad-spectrum protease inhibitor which are involved in various biological processes such as inflammation, cell growth, and blood clotting (2). α2M can also bind to and regulate cytokines and growth factors, thus influencing the immune system response (3). α2M also may play a role in various cancers and has been implicated in the development of some cancers and also as a tumor suppressor in other cancer types (4). α2M may act as an anticancer agent by inhibiting proteases, which are enzymes that can...
Post a Comment
Read more

A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS - GP surgeries providing medicines to patients (ISSN 2753-8176 (online))

A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS - GP surgeries providing medicines to patients (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre 24 Grosvenor Street Chester CH1 2DD info@gwyntwr1386.com The problem NHS 111 Key problems with the burden it places on emergency and ambulance services. Improvements need to be made to the NHS 111 service to make sure the triage software it uses prioritises patients accurately and minimises inappropriate referrals to the ambulance service. Also, the introduction of the NHS111 online service had a small impact on the number of triaged and total calls. However, evidence suggests an increase in the overall number of disposition recommendations (ambulance, emergency department and primary care) for NHS 111 telephone and online services combined following the int...
Post a Comment
Read more

Social café supporting mental health and to combat discrimination - Business Plan Draft (ISSN 2753-8176 (online))

Social café supporting mental health and to combat discrimination - Business Plan Draft (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com - Objectives - Providing a safe space Mental health resources Raising awareness against discrimination Raise funding for NHS & Social Care by providing food and drinks Offer employment for marginalized individuals Host support groups Promote mental wellness - Location- Near mental health services, universities, community centres -Environment- Warm, inclusive, stigma-free, accessible place Staff should be trained about mental health and discrimination Quite areas for reflection and conversation -Partnerships- Mental health organizations Charities Advocacy groups -Services- Affordable healthy food and drinks Mental health resources: leaflets, helplines and self care guides Events like art th...
Post a Comment
Read more

Private Pharmacy/Social Care Services - NHS Innovation Service submission (ISSN 2753-8176 (online))

Private Pharmacy/Social Care Services - NHS Innovation Service submission (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Description of innovation We can provide you domiciliary care including personal care and moving & handling, as well as provide you over-the-counter and pharmacy medicines and private prescriptions. We can also review your medicines use and contact GP surgeries and other healthcare units regarding management of your appointments and prescriptions, to expedite social care assessments . This service aims to provide a better integration between health and social care services leading to better outcomes for patients and service users. Also as these services are provided by self-employed pharmacists and self-employed carers or self-employed social workers (directly employed by an individual, or related third party, or with an agreement to work dir...
Post a Comment
Read more

Parkinson’s disease and the Parkinsonisms (ISSN 2753-8176 (online))

Parkinson’s disease and the Parkinsonisms (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Parkinson’s Disease was first described by James Parkinson in 1817. Idiopathic Parkinson's disease is caused by a loss of nerve cells in the part of the brain called the substantia nigra which produce dopamine. Dopamine acts as a messenger between the parts of the brain and nervous system that help control and co-ordinate body movements. The loss of these nerve cells is a slow process and Parkinson's disease symptoms' usually start to develop when around 50% of the nerve cell activity in the substantia nigra have been lost (1). Parkinson's disease is a common condition in elderly people. About 137,000 people were living with Parkinson's disease in the UK. The prevalence rate was 286.5 per 100,000 person-years (2). The symptoms of Parkinson's disease ...
Post a Comment
Read more

Music therapy, dementia and Alzheimer’s disease – a review (ISSN 2753-8176 (online))

Music therapy, dementia and Alzheimer’s disease – a review (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Health & Social Care, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Music shows a positive effect on cognitive functioning and music-making has a small but statistically significant effect on cognitive functioning for older adults with probable mild cognitive impairment (MCI) or dementia (1). Music therapy (MT) positively affects mood, neuropsychiatric behaviour, apathy, communication and physical functions for dementia improving symptomatology. Also, behavioural/psychological symptoms improve in severe dementia, and memory and verbal fluency improve in mild Alzheimer's disease. Both active (playing music) and receptive (listening to music) methods are used for dementia (2). Also, MT besides improving patients' symptomatology also helps with caregivers' burden(3). Also, music based interventions (MBIs) consisting o...
Post a Comment
Read more