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A2M in Prostate Cancer – short report (ISSN 2753-8176 (online))

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A2M in Prostate Cancer – short report (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. We study the possibility that A2M can play a role in prostate cancer (PC) progression. Prostate cancer is the second most common type of cancer in the world. Moreover, is the fifth leading cause of cancer-related mortality among men (1). About 99% of cases occur after age 50 (1). Early prostate cancer symptoms are often similar to those of benign prostatic hyperplasia and include frequent urination, nocturia (increased urination at night), difficulty starting and maintaining a steady stream of urine, hematuria (blood in the urine), dysuria (painful urination) as well as fatigue due to anemia, and bone pain (1). Like early cancer, meta...
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A2M in Lung Cancer – short report (ISSN 2753-8176 (online))

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A2M in Lung Cancer – short report (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, 58 Grove Road, Birkenhead, CH42 XX. info@gwyntwr1386.com Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. Alpha-2-macroglobulin (A2M) is a large protein found in the blood which is mainly produced by the liver. A2M is the largest major non-immunoglobulin protein in human plasma. We study the possibility that A2M can play a role in lung cancer initiation and/or progression. Here we analyse by proteomic analysis, the presence of A2M (P010230) in the precipitates derived from conditioned media of different lung cancer cell lines and lung cancer-derived bone metastases (mets) (table 1). We find out that control cell WI38 presents quite a big Mascot score (993), while primary lung cancer cell lines present an average Mascot score level (315-415)...
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A2M in Colorectal Cancer (ISSN 2753-8176 (online))

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A2M in Colorectal Cancer (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Colorectal cancer (CRC), is the development of cancer from the colon or rectum (parts of the large intestine). Staging of the cancer is based on both radiological and pathological findings. As with most other forms of cancer, tumor staging is based on the TNM system which considers how much the initial tumor has spread and the presence of metastases in lymph nodes and more distant organs. We analyze the possibility that A2M (alpha-2-macroglobulin) can play a role in CRC initiation and/or progression. Here, we analyze by proteomics the presence of A2M in the conditioned culture media of different CRC cell lines either overexpressing P53 or knockout for P53 (3) or treated with vitamin D and from different stages of tumor progression and benign tissues (table 1). We found out th...
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A2M function in pancreatic cancer in mouse (ISSN 2753-8176 (online))

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A2M function in pancreatic cancer in mouse (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Introduction, results and discussion In our previous article we analyzed the hypothesis that A2M predicts cancer appearance or progression in the breast (1) and in the skin (2), now we analyse if this hypothesis might be true as well in the case of pancreatic cancer in mouse. The most common type of pancreatic cancer (PC) is adenocarcinoma, which accounts for 90% of the cases. Around 1-2% of the PC cases have a neuroendocrine origin, arising from the hormone-producing cells of the pancreas being in general less aggressive than the adenocarcinoma (3). In table 1, we found Mascot scores for two different mouse normal pancreas tissue CM samples (one shows a significant Mascot Score, while the other shows no A2M), PanIn cell ...
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Does A2M predicts cancer appearance or progression in skin? (ISSN 2753-8176 (online))

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Does A2M predicts cancer appearance or progression in skin? (ISSN 2753-8176 (online)) 1.Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD. info@gwyntwr1386.com Introduction In our previous article we analyzed the hypothesis that A2M predicts cancer appearance or progression in the breast (1), now we analyse if this hypothesis might be true as well in the case of the skin. The interstitial fluid and the deriving lymph are in direct contact with the cellular layer of each organ. Therefore, the analysis of the composition of the lymphatic fluid (LF) may provide precise pathological biochemical and cellular information about an organ including the skin (2). For these reasons, we collected LF samples both from healthy patients and cutaneous melanoma (CM) patients suffering from different stages of the disease, and submitted these samples to proteomic analysis and analyzed the expression of A2M in these sa...
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Does Alpha-2-macroglobulin (α2M) predicts breast cancer development or progression? (ISSN 2753-8176 (online))

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Does Alpha-2-macroglobulin (α2M) predicts breast cancer development or progression? (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre, 24 Grosvenor Street, Chester, CH1 2DD, info@gwyntwr1386.com Introduction, Results and Discussion Alpha-2-macroglobulin (α2M) is a large protein found in the blood which is mainly produced by the liver. α2M is the largest major non-immunoglobulin protein in human plasma (1). It functions as a broad-spectrum protease inhibitor which are involved in various biological processes such as inflammation, cell growth, and blood clotting (2). α2M can also bind to and regulate cytokines and growth factors, thus influencing the immune system response (3). α2M also may play a role in various cancers and has been implicated in the development of some cancers and also as a tumor suppressor in other cancer types (4). α2M may act as an anticancer agent by inhibiting proteases, which are enzymes that can...
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A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS - GP surgeries providing medicines to patients (ISSN 2753-8176 (online))

A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS - GP surgeries providing medicines to patients (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Health & Social Care, Harold Tomlin Day Centre 24 Grosvenor Street Chester CH1 2DD info@gwyntwr1386.com The problem NHS 111 Key problems with the burden it places on emergency and ambulance services. Improvements need to be made to the NHS 111 service to make sure the triage software it uses prioritises patients accurately and minimises inappropriate referrals to the ambulance service. Also, the introduction of the NHS111 online service had a small impact on the number of triaged and total calls. However, evidence suggests an increase in the overall number of disposition recommendations (ambulance, emergency department and primary care) for NHS 111 telephone and online services combined following the int...
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