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A Plasma-based Apolipoprotein ELISA Assay to detect Neuropsychiatric Disorders – Project Proposal (ISSN 2753-8176 (online))

A Plasma-based Apolipoprotein ELISA Assay to detect Neuropsychiatric Disorders – Project Proposal (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Protocol title A Plasma-based Apolipoprotein ELISA Assay to detect Neuropsychiatric Disorders Protocol identifying number Version 0.1 Date 14/07/2024 Name and address of the Sponsor and monitor Name and title of the person(s) authorised to sign the protocol and the protocol amendment(s) for the Sponsor Ana Pedro, MPHARM, PhD Name and title of the investigator(s) who is (are) responsible for conducting the study, and the address and telephone number(s) of the study site(s). Ana Pedro, MPHARM, PhD Name(s) and address(es) of the clinical laboratory(ies) and other medical and/or technical department(s) and/or institutions involved in the study Background Information Neuropsychiatric disorders (NDs) are a
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A Plasma-based Apolipoprotein and p-tau Elisa Assay to detect Alzheimer’s and differentiate from other dementia types for the NHS (ISSN 2753-8176 (online))

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A Plasma-based Apolipoprotein and p-tau Elisa Assay to detect Alzheimer’s and differentiate from other dementia types for the NHS (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com A - Please select the innovation sector In-vitro diagnostic B- Please provide a brief description of the innovation including relevant disease area(s) and target patient and service user population(s) Apolipoproteins are “any of various proteins that combine with a lipid to form a lipoprotein, such as HDL and LDL”, or “The protein components of lipoproteins, which remain after the lipids to which the proteins are bound have been removed”(1). Apolipoproteins are reported to be linked to many neurodegenerative disorders. APOE plays a role in many brain disorders, including Alzheimer’s disease, mild cognitive impairment, multiple sclerosis, traumatic brain injury, and maybe in more some others
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A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS (ISSN 2753-8176 (online))

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A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS (ISSN 2753-8176 (online)) 1. Ana Pedro 1.Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com The problem NHS 111 Key problems with the burden it places on emergency and ambulance services. Improvements need to be made to the NHS 111 service to make sure the triage software it uses prioritises patients accurately and minimises inappropriate referrals to the ambulance service. Also, the introduction of the NHS111 online service had a small impact on the number of triaged and total calls. However, evidence suggests an increase in the overall number of disposition recommendations (ambulance, emergency department and primary care) for NHS 111 telephone and online services combined following the introduction of the NHS 111 online service.
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AN HEMOGLOBIN TEST FOR CANCER SCREENING (ISSN 2753-8176 (online))

AN HEMOGLOBIN TEST FOR CANCER SCREENING (ISSN 2753-8176 (online)) Ana Pedro1,2 1.Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Under normal circumstances and at normal ambient oxygen tension, the red blood cell life span and the rate of effective red blood cell production determine the circulating red blood cell mass. Anemia, which can be defined in a functional way as the lack of sufficient red blood cells to maintain adequate tissue oxygenation, develops when the demand for new red blood cells exceeds the capacity of the bone marrow to produce them. Acquired anemia is always a consequence of a pimary disorder, which must be identified to make sure that a corrective therapy is administered. In patients with solid tumors, anemia can be caused by blood loss which can be either intrinsic or iatrogenic, iron or folic acid deficiency or hemolysis (autoimmune, traumatic, or drug-induced); or bone marrow failure due to t
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NHS App and hospital admissions – short proposal summary (ISSN 2753-8176 (online))

NHS App and hospital admissions – short proposal summary (ISSN 2753-8176 (online)) Ana Pedro1,2 1.Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Usually there is a lot of troubles when transmitting information about patients discharged in hospitals to GP surgeries, medicines often are not correctly updated. Failure to properly conciliate patients medicines in hospital admissions and discharges may end up in hospital readmissions, adverse effects and poor treatment outcomes. We propose that all of a patient journey since it is admitted into a hospital until it is discharged should be totally recorded at NHS App in particular medication optimisation since getting into hospital, while in hospital and on discharge. NHS App should incorporate BNF, NICE guidelines, medicines interactions and renal and hepatic clearance tools as well as patients clinical tests results while in hospital. All the patie
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A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS - ISSN 2753-8176 (online)

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A triage centre and a medicine delivery and treatment monitoring service for patients with heart disease/ hypertension/diabetes using the NHS App for the NHS -ISSN 2753-8176 (online) Ana Pedro1 1Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com Part A – Triage Centre Gwyntwr1386 Healthcare CIC (a future employee-owned company) is looking forward to set up a triage centre with clinical pharmacists for the NHS which would use PGDs or pharmacist independent prescribing in the area of minor/acute illnesses and the NHS App (fig.1, green, 1-3). These pharmacists would receive calls from patients or chat messages etc and they would solve the problem straight away by prescribing or supplying medicines through PGDs, or just advising or would signpost to GP, dentist, opticians, A&E, ambulances, etc according to the seriousness of the situation. The patients would pay a small subscription fee or a small service
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“An E-Medicine Delivery and Treatment Monitoring Service For Patients With Heart Disease/ Hypertension/Diabetes In The NHS” - Project proposal ISSN 2753-8176 (online)

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Ana Pedro1 1Gwyntwr1386 Pharmacy, Regus Chester Business Park, Heronsway, Chester, CH49QR, UK. info@gwyntwr1386.com There is a high prevalence of diabetes and it continues to increase. The adherence to oral antidiabetics ranges from 36% to 93% (1). Moreover, improving the adherence to treatment in diabetes patients will lead to a better glycaemic control and could in the longterm reduce the incidence of micro- and macrovascular complications associated with diabetes (2,3). Also, most MCA (medicine-compliance aids) patients are elderly and suffer of combined cardiovascular disease including diabetes (4). Gwyntwr1386 Pharmacy, intends to provide a new, online clinical delivery and treatment monitoring service for the NHS, which will be coupled to the NHSapp, based on digital medication adherence packaging such as blister-packs pill bottles, pre-filled syringes and monitoring POC devices such as the Free Libre Sensor and smart blood pressure monitors. The digital medi
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